Unknown

Dataset Information

0

SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?


ABSTRACT:

Introduction

Thyroid dysfunctions associated with SARS-CoV-2 are emerging in scientific literature. During the second COVID-19 epidemic spread, we evaluated a patient with the suspect of subacute thyroiditis.

Methods and results

Specimen from fine-needle aspiration of a hypoechoic undefined area was analyzed for cytology and for SARS-CoV-2 detection. SARS-CoV-2 was retrieved by real-time polymerase chain reaction on the cytologic sample, which was then cultured on Vero E6 cells and demonstrated to be cytopathic. Whole-genome sequence was deposited. Histological exam diagnosed a rare case of primary thyroid sarcoma with diffuse and strong expression of mouse double minute 2 homolog (MDM2) oncoprotein. Ultrastructural examination confirmed, in several neoplastic cells, the presence of viral particles in cytoplasmic vacuoles.

Conclusions

In our hypothesis, SARS-CoV-2 and sarcoma coexistence could represent a synergistic interplay, ultimately favoring both viral persistence and tumor proliferation: the overexpression of MDM2 in tumor cells might have generated a favorable immunological niche for SARS-CoV-2 localization and, in turn, SARS-CoV-2 could have favored tumor growth by inducing MDM2-mediated p53 downregulation. Functional studies are needed to confirm this suggestive pathway.

SUBMITTER: Tanda ML 

PROVIDER: S-EPMC8727071 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?

Tanda M L ML   Ippolito S S   Gallo D D   Baj A A   Novazzi F F   Genoni A A   Annoni M M   Mancini N N   Clementi N N   Finzi G G   Piantanida E E   Premoli P P   Lai A A   Dalla Gasperina D D   Maggi F F   Uccella S S  

Journal of endocrinological investigation 20220105 5


<h4>Introduction</h4>Thyroid dysfunctions associated with SARS-CoV-2 are emerging in scientific literature. During the second COVID-19 epidemic spread, we evaluated a patient with the suspect of subacute thyroiditis.<h4>Methods and results</h4>Specimen from fine-needle aspiration of a hypoechoic undefined area was analyzed for cytology and for SARS-CoV-2 detection. SARS-CoV-2 was retrieved by real-time polymerase chain reaction on the cytologic sample, which was then cultured on Vero E6 cells an  ...[more]

Similar Datasets

| S-EPMC7953946 | biostudies-literature
| S-SCDT-EMBOR-2020-51252V1 | biostudies-other
| S-EPMC7176927 | biostudies-literature
| S-EPMC8428263 | biostudies-literature
| S-EPMC9783100 | biostudies-literature
| S-BSST379 | biostudies-other
| S-SCDT-EMBOJ-2021-108588 | biostudies-other
| S-EPMC9346336 | biostudies-literature
| S-EPMC4358988 | biostudies-literature
| S-EPMC3951685 | biostudies-literature