Identification and External Validation of a Transcription Factor-Related Prognostic Signature in Pediatric Neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is a common solid tumor originating from the sympathetic nervous system, commonly found in children, and it is one of the leading causes of tumor-related deaths in children. In addition to pathological features, molecular-level features, such as how much gene expression is present and the mutational profile, may provide useful information for the precise treatment of neuroblastoma. Transcription factors (TFs) play an important regulatory role in all aspects of cellular life activities. But there are currently no studies on transcription factor-based biomarkers of neuroblastoma prognosis, and this study is much needed.

Methods

We downloaded RNA transcriptome data and clinical data from the TARGET database to construct a prognostic model. The prognosti

SUBMITTER: Wang R 

PROVIDER: S-EPMC8727167 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature