Variation and transmission of the human gut microbiota across multiple familial generations.

ABSTRACT: Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, sharing of microbiota features within families has mostly been assessed between parents and their direct offspring. Here we investigate the potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (n = 102) spanning 3 to 5 generations over the same female bloodline. We observe microbiome community composition associated with kinship, with seven low abundant genera displaying familial distribution patterns. While kinship and current cohabitation emerge as closely entangled variables, our explorative analyses of microbial genotype

SUBMITTER: Valles-Colomer M 

PROVIDER: S-EPMC8727295 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature