Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella-based trophic network.

ABSTRACT: Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic c

SUBMITTER: de Goffau MC 

PROVIDER: S-EPMC8727306 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature