Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice.

ABSTRACT:

Background

Accumulating evidence indicates that high-fat diet (HFD) is a controllable risk factor for osteoporosis, but the underlying mechanism remains to be elucidated. As a primary biological barrier for nutrient entry into the human body, the composition and function of gut microbiota (GM) can be altered rapidly by HFD, which may trigger abnormal bone metabolism. In the current study, we analyzed the signatures of GM and serum metabolomics in HFD-induced bone loss and explored the potential correlations of GM and serum metabolites on HFD-related bone loss.

Methods

We conducted a mouse model with HFD-induced bone loss through a 12-week diet intervention. Micro-CT, Osmium-μCT, and histological analyses were used to observe bone microstructure and bone marrow adipose tissue

SUBMITTER: Lu L 

PROVIDER: S-EPMC8727351 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature