Serum Free Fatty Acids Independently Predict Adverse Outcomes in Acute Heart Failure Patients.

ABSTRACT: Background: Perturbation of energy metabolism exacerbates cardiac dysfunction, serving as a potential therapeutic target in congestive heart failure. Although circulating free fatty acids (FFAs) are linked to insulin resistance and risk of coronary heart disease, it still remains unclear whether circulating FFAs are associated with the prognosis of patients with acute heart failure (AHF). Methods: This single-center, observational cohort study enrolled 183 AHF patients (de novo heart failure or decompensated chronic heart failure) in the Second Affiliated Hospital, Zhejiang University School of Medicine. All-cause mortality and heart failure (HF) rehospitalization within 1 year after discharge were investigated. Serum FFAs were modeled as quartiles as well as a continu

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8727366 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature