Menopausal hormone therapy and risk of oesophageal adenocarcinoma in a population-based cohort study.

ABSTRACT:

Background

Oesophageal adenocarcinoma is characterised by a strong male predominance. We aimed to test the hypothesis that menopausal hormonal therapy decreases the risk of oesophageal adenocarcinoma.

Methods

This population-based cohort study included all women who used systemic menopausal hormonal therapy (exposed) in Sweden between 2005 and 2018. For each exposed participant, five randomly selected female age-matched non-users of menopausal hormonal therapy (unexposed) were included. Cox regression provided hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, smoking-related diagnoses, Helicobacter pylori eradication, use of non-steroidal anti-inflammatory drugs/aspirin, use of statins and hysterectomy.

Results

The study included 296,964 users of

SUBMITTER: Xie SH 

PROVIDER: S-EPMC8727583 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature