TIM3⁺ cells in gastric cancer: clinical correlates and association with immune context.

ABSTRACT:

Background

T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a crucial immune checkpoint and is considered as an emerging target for cancer treatment. However, the clinical significance and immune-related role of TIM3⁺ cells in gastric cancer remain unknown. This study aimed to investigate the clinical significance of tumour-infiltrating TIM3⁺ cells and their association with immune contexture in gastric cancer.

Methods

This study enrolled three cohorts, including 436 tumour tissue microarray specimens and 58 fresh tumour tissues of gastric cancer patients from Zhongshan Hospital, and 330 transcriptional data from The Cancer Genome Atlas. TIM3⁺ cells and their association with CD8⁺ T cells were evaluated by immu

SUBMITTER: Chen K 

PROVIDER: S-EPMC8727614 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature