Parental age and retinoblastoma-a retrospective study of demographic data and genetic analysis.

ABSTRACT:

Objective

To determine the association between the parental age gap and the absolute parental age with the risk of retinoblastoma (RB) development in an offspring.

Methods

RB individuals diagnosed between March 2013 and December 2019 in a single tertiary eye care centre were included. We recorded the demographic data, parental age and RB1 gene mutation status in the patient's tumour, blood and the parental blood. We categorised RB1 mutation inheritance as sporadic RB with somatic mutations (only present in tumour), heritable RB with de novo (present in patient's blood) and familial (present in patient and parents' blood) germline mutations. The statistical significance was confirmed by Fisher's exact/Chi-square test.

Results

Out of 259 RB patients, 247 were included i

SUBMITTER: Tanwar M 

PROVIDER: S-EPMC8727630 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature