Protein Signatures of NK Cell-Mediated Melanoma Killing Predict Response to Immunotherapies.

ABSTRACT: Despite impressive advances in melanoma-directed immunotherapies, resistance is common and many patients still succumb to metastatic disease. In this context, harnessing natural killer (NK) cells, which have thus far been sidelined in the development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment. To identify molecular determinants of NK cell-mediated melanoma killing (NKmK), we quantified NK-cell cytotoxicity against a panel of genetically diverse melanoma cell lines and observed highly heterogeneous susceptibility. Melanoma protein microarrays revealed a correlation between NKmK and the abundance and activity of a subset of proteins, including several metabolic factors. Oxidative phoshorylation, measured by oxygen consumption rate, negati

SUBMITTER: Cappello S 

PROVIDER: S-EPMC8727679 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature