The <i>In Vivo</i> Transcriptomic Blueprint of <i>Mycobacterium tuberculosis</i> in the Lung.

ABSTRACT: Mycobacterium tuberculosis (Mtb) genes encoding proteins targeted by vaccines and drugs should be expressed in the lung, the main organ affected by Mtb, for these to be effective. However, the pulmonary expression of most Mtb genes and their proteins remains poorly characterized. The aim of this study is to fill this knowledge gap. We analyzed large scale transcriptomic datasets from specimens of Mtb-infected humans, TB-hypersusceptible (C3H/FeJ) and TB-resistant (C57BL/6J) mice and compared data to in vitro cultured Mtb gene-expression profiles. Results revealed high concordance in the most abundantly in vivo expressed genes between pulmonary Mtb transcriptomes from different datasets and different species. As expected, this c

SUBMITTER: Coppola M 

PROVIDER: S-EPMC8727759 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature