Persistent Lung Inflammation After Clinical Resolution of Community-Acquired Pneumonia as Measured by ¹⁸FDG-PET/CT Imaging.

ABSTRACT:

Background

Survivors of community-acquired pneumonia (CAP) are at increased risk of cardiovascular disease, cognitive and functional decline, and death, but the mechanisms remain unknown.

Research question

Do CAP survivors have evidence of increased inflammatory activity in their lung parenchyma on 2-deoxy-2-[¹⁸F]fluoro-d-glucose (¹⁸FDG)-PET/CT imaging after clinical resolution of infection?

Study design and methods

We obtained ¹⁸FDG-PET/CT scans from 22 CAP survivors during their hospitalization with pneumonia (acute CAP) and 30 to 45 days after hospital discharge (post-CAP). In each set of scans, we assessed the lungs for foci of increased ¹⁸FDG uptake by visual interpretation and by total pulmonary glycolytic activity (tP

SUBMITTER: Corrales-Medina VF 

PROVIDER: S-EPMC8727848 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature