Treating sarcoidosis-associated progressive multifocal leukoencephalopathy with infliximab.

ABSTRACT: Although most of the progressive multifocal leukoencephalopathy cases in sarcoidosis patients are explained by the treatment with immunosuppressive drugs, it is also reported in treatment-naive sarcoidosis patients, which implies a general predisposition of sarcoidosis patients for progressive multifocal leukoencephalopathy. Indeed, it was shown that active sarcoidosis patients have increased regulatory T cell frequencies which could lead to a subsequent systemic immunosuppression. However, if sarcoidosis with systemic changes of T cell subsets frequencies constitute a risk factor for the development of progressive multifocal leukoencephalopathy, which could then be counteracted by sarcoidosis treatment, is not known. In this cohort study, we included, characterized and followed-up six pat

SUBMITTER: Rosenkranz SC 

PROVIDER: S-EPMC8727989 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature