Identification of Diagnostic Markers Correlated With HIV⁺ Immune Non-response Based on Bioinformatics Analysis.

ABSTRACT: Background: HIV-infected immunological non-responders (INRs) are characterized by their inability to reconstitute CD4⁺ T cell pools after antiretroviral therapy. The risk of non-AIDS-related diseases in INRs is increased, and the outcome and prognosis of INRs are inferior to that of immunological responders (IRs). However, few markers can be used to define INRs precisely. In this study, we aim to identify further potential diagnostic markers associated with INRs through bioinformatic analyses of public datasets. Methods: This study retrieved the microarray data sets of GSE106792 and GSE77939 from the Gene Expression Omnibus (GEO) database. After merging two microarray data and adjusting the batch effect, differentially expressed genes (DEGs) were identified. Gene O

SUBMITTER: Bai R 

PROVIDER: S-EPMC8727996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature