A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration.

ABSTRACT: Migrating cell collectives are key to embryonic development but also contribute to invasion and metastasis of a variety of cancers. Cell collectives can invade deep into tissues, leading to tumor progression and resistance to therapies. Collective cell invasion is also observed in the lethal brain tumor glioblastoma (GBM), which infiltrates the surrounding brain parenchyma leading to tumor growth and poor patient outcomes. Drosophila border cells, which migrate as a small cell cluster in the developing ovary, are a well-studied and genetically accessible model used to identify general mechanisms that control collective cell migration within native tissue environments. Most cell collectives remain cohesive through a variety of cell-cell adhesion proteins during their migration through tissu

SUBMITTER: Kotian N 

PROVIDER: S-EPMC8728034 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature