Serum potassium as a predictor of adverse clinical outcomes in patients with increasing comorbidity burden.

ABSTRACT:

Aims

The aim of this study was to establish whether patients with multiple comorbidities may be at elevated risk of hyperkalaemia (HK), a potentially life-threatening electrolyte imbalance, and the associated adverse clinical outcomes.

Methods and results

This was a retrospective, observational cohort study using UK primary and secondary care data. Adult patients with at least one of: resistant hypertension, chronic kidney disease stage 3+, dialysis, heart failure (HF), and diabetes, were eligible for inclusion. According to their diagnoses, patients were grouped into overlapping cohorts that were updated as multimorbidity progressed. Outcomes of interest were incident HK, all-cause mortality (ACM), and major adverse cardiovascular events (MACE). A total of 673 686 patients

SUBMITTER: Tafesse E 

PROVIDER: S-EPMC8728036 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature