Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations.

ABSTRACT:

Aims

Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of renin-angiotensin-aldosterone system (RAAS) inhibitors and β-blockers with long-term survival.

Methods and results

We identified 150 TGA-AtrSO patients [median age 30 years (interquartile range 25-35), 63% male] included in the CONCOR registry from five tertiary medical centres with subsequent li

SUBMITTER: Woudstra OI 

PROVIDER: S-EPMC8728040 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature