Evaluation of the incidence and clinical significance of WT-1 expression in uterine serous carcinoma.

ABSTRACT:

Background

Wilms tumor gene 1 (WT1) expression is a hallmark of ovarian serous carcinoma and considered to be diagnostic marker of these tumors, differentiating them from uterine serous carcinoma (USC), historically thought to rarely express WT1. However, more recent data indicates a significant percentage of USC may express WT1. The clinical implications of WT1 positivity in USC remain unclear.

Methods

A multicenter retrospective analysis of patients with USC was conducted from 2000 to 2019. Inclusion criteria were patients who had undergone comprehensive surgical staging/tumor debulking with archival tissue available for WT1 assessment via immunohistochemistry (IHC). Chemosensitive patients were defined as those recurring >6 months from last platinum-based chemotherapy. Pr

SUBMITTER: McEachron J 

PROVIDER: S-EPMC8728043 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature