Immune Response to Hepatitis B Virus Vaccine Among People Living With HIV: A Meta-Analysis.

ABSTRACT:

Background

There is conflicting evidence about whether a double dose of the hepatitis B virus (HBV) vaccine induces better immunity than the standard-dose vaccine for people living with HIV (PLWH). This study provides a meta-analysis that summarizes the efficacy of HBV vaccine regimens among HIV-infected patients, clarifying the role of particular factors such as dose and frequency of vaccination in vaccine responsiveness and highlighting the need for evidence-based practice to assess HBV vaccination among PLWH.

Methods

Randomized clinical trials (RCTs) and prospective studies reporting vaccination response rates among PLWH were found through a search of PubMed, Cochrane, and the Web of Science. The key outcome was vaccine response. A random-effects model was used to estimat

SUBMITTER: Tian Y 

PROVIDER: S-EPMC8728056 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature