Explaining Ayurvedic preparation of Rasasindura, its toxicological effects on NIH3T3 cell line and zebrafish larvae.

ABSTRACT: Rasasindura is a mercury-based medicinal formulation that contains HgS (>99%). Although cinnabar ore was a well-known mineral in the past, the Ayurvedic practitioner adopted a critical and tedious procedure for the preparation of Rasasindura. Therefore, it is essential to understand the Ayurvedic process in the perspective of material science. Further, a toxicity study is also required as mercury is the main component in Rasasindura. Here, in the present study, we characterized Rasasindura and one of its intermediates (Kajjali) to understand the physicochemical changes that occur in the Ayurvedic process. Furthermore, we have assessed the toxicity of Kajjali and Rasasindura in NIH3T3 cell lines and zebrafish larvae. XRD analysis of Rasasindura confirms it as a highly pure α-HgS with size r

SUBMITTER: Biswas S 

PROVIDER: S-EPMC8728081 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature