Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
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ABSTRACT:
SUBMITTER: Dai H
PROVIDER: S-EPMC8728105 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
Dai Hongyue H Lou Shan S Zhang Yanbo Y Thanawala Monica M Huang Kai-Chih KC Ji Lexiang L Carden Sarah S Liao Tiffany T Abbassi Mandana M Shu Chengyi J CJ Lantermann Alexandra A Sadaghiani Masoud M Blom Daniel D Wagner John J Huang Pearl P
FASEB bioAdvances 20211004 1
Tumor innervation has recently been documented and characterized in various settings and tumor types. However, the role that nerves innervating tumors play in the pathogenesis of cancer has not been clarified. In this study, we searched for neural signaling from bulk RNA sequencing from The Cancer Genome Atlas (TCGA) dataset and looked for patterns of interactions between different cell types within the tumor environment. Using a presynapse signature (PSS) as a probe, we showed that multiple str ...[more]
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