TF-Marker: a comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human.

ABSTRACT: Transcription factors (TFs) play key roles in biological processes and are usually used as cell markers. The emerging importance of TFs and related markers in identifying specific cell types in human diseases increases the need for a comprehensive collection of human TFs and related markers sets. Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/), aiming to provide cell/tissue-specific TFs and related markers for human. By manually curating thousands of published literature, 5905 entries including information about TFs and related markers were classified into five types according to their functions: (i) TF: TFs which regulate expression of the markers; (ii) T Marker: markers which are regulated by the TF; (iii) I Marker: markers which influence the acti

SUBMITTER: Xu M 

PROVIDER: S-EPMC8728118 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature