PncsHub: a platform for annotating and analyzing non-classically secreted proteins in Gram-positive bacteria.

ABSTRACT: From industry to food to health, bacteria play an important role in all facets of life. Some of the most important bacteria have been purposely engineered to produce commercial quantities of antibiotics and therapeutics, and non-classical secretion systems are at the forefront of these technologies. Unlike the classical Sec or Tat pathways, non-classically secreted proteins share few common characteristics and use much more diverse secretion pathways for protein transport. Systematically categorizing and investigating the non-classically secreted proteins will enable a deeper understanding of their associated secretion mechanisms and provide a landscape of the Gram-positive secretion pathway distribution. We therefore developed PncsHub (https://pncshub.erc.monash.edu/), the first universal

SUBMITTER: Dai W 

PROVIDER: S-EPMC8728121 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature