R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation.

ABSTRACT: R-loops play versatile roles in many physiological and pathological processes, and are of great interest to scientists in multiple fields. However, controversy about their genomic localization and incomplete understanding of their regulatory network raise great challenges for R-loop research. Here, we present R-loopBase (https://rloopbase.nju.edu.cn) to tackle these pressing issues by systematic integration of genomics and literature data. First, based on 107 high-quality genome-wide R-loop mapping datasets generated by 11 different technologies, we present a reference set of human R-loop zones for high-confidence R-loop localization, and spot conservative genomic features associated with R-loop formation. Second, through literature mining and multi-omics analyses, we curate the most compr

SUBMITTER: Lin R 

PROVIDER: S-EPMC8728142 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature