POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins.

ABSTRACT: RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation. Accurate identification of RBP binding sites in multiple cell lines and tissue types from diverse species is a fundamental endeavor towards understanding the regulatory mechanisms of RBPs under both physiological and pathological conditions. Our POSTAR annotation processes make use of publicly available large-scale CLIP-seq datasets and external functional genomic annotations to generate a comprehensive map of RBP binding sites and their association with other regulatory events as well as functional variants. Here, we present POSTAR3, an updated database with improvements in data collection, annotation infrastructure, and analysis that support the annotation of post-transcriptional regulation in multiple species

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8728292 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature