Relationship between osteonecrosis and antiphospholipid antibodies in patients with systemic lupus erythematosus: a systematic review protocol.

ABSTRACT:

Introduction

Osteonecrosis (ON) is characterised by the destruction of the normal blood supply to the bone tissue. ON is the main cause of disability in patients with systemic lupus erythematosus (SLE). Studies have reported the existence of many risk factors for SLE complicated by ON, including the use of high-dose glucocorticoids and high disease activity. The correlation between antiphospholipid antibodies (aPLs) and ON in SLE has been controversial. We aim to conduct a systematic review of the literature related to SLE, aseptic ON and aPLs, to provide a reference for the clinical screening of high-risk patients and for early prevention.

Methods and analysis

The following six databases will be searched: MEDLINE/PubMed, Embase, Web of Science, Chinese Biomedical Literature

SUBMITTER: Wei Q 

PROVIDER: S-EPMC8728347 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature