Prognostic Significance of CCNB2 Expression in Triple-Negative Breast Cancer.

ABSTRACT:

Purpose

The aim of this study was to explore potential gene therapy targets for triple-negative breast cancer (TNBC).

Patients and methods

Three gene expression profiles (GSE64790, GSE62931, and GSE38959) from the Gene Expression Omnibus (GEO) database were analyzed. The GEO2R analysis tool was used to screen for differentially expressed genes (DEGs) between TNBC and normal tissues, followed by Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the DEGs. The protein-protein interaction network of DEGs was visualized using Metascape to identify the core genes. Subsequently, transcriptional data for the core genes in patients with breast cancer were investigated in the ONCOMINE database. Kaplan-Meier survival analysis

SUBMITTER: Cao J 

PROVIDER: S-EPMC8728388 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature