Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis.

ABSTRACT:

Importance

Essential tremor (ET) is one of the most common movement disorders, affecting 5% of the general population older than 65 years. Common variants are thought to contribute toward susceptibility to ET, but no variants have been robustly identified.

Objective

To identify common genetic factors associated with risk of ET.

Design, setting, and participants

Case-control genome-wide association study. Inverse-variance meta-analysis was used to combine cohorts. Multicenter samples collected from European populations were collected from January 2010 to September 2019 as part of an ongoing study. Included patients were clinically diagnosed with or reported having ET. Control individuals were not diagnosed with or reported to have ET. Of 485 250 individuals, data for 4

SUBMITTER: Liao C 

PROVIDER: S-EPMC8728658 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature