Targeting tumor microenvironment and metastasis in children with solid tumors.

ABSTRACT:

Purpose of review

The prognosis of pediatric patients with metastatic solid tumors remains poor, necessitating development of novel therapeutic strategies. The biology of the pediatric tumor microenvironment (TME) presents obstacles for the efficacy of current therapeutic approaches including immunotherapies. Targeting various aspects of the TME in pediatric patients with solid tumors represents a therapeutic opportunity that may improve outcomes. Here we will discuss recent advances in characterization of the TME, and clinical advances in targeting the immune, vascular, and stromal aspects of the TME.

Recent findings

Although immunotherapies have shown limited success in the treatment of pediatric solid tumor patients thus far, optimization of these approaches to overcome t

SUBMITTER: Wessel KM 

PROVIDER: S-EPMC8728685 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature