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Oncolytic Viruses and Cancer, Do You Know the Main Mechanism?

ABSTRACT: The global rate of cancer has increased in recent years, and cancer is still a threat to human health. Recent developments in cancer treatment have yielded the understanding that viruses have a high potential in cancer treatment. Using oncolytic viruses (OVs) is a promising approach in the treatment of malignant tumors. OVs can achieve their targeted treatment effects through selective cell death and induction of specific antitumor immunity. Targeting tumors and the mechanism for killing cancer cells are among the critical roles of OVs. Therefore, evaluating OVs and understanding their precise mechanisms of action can be beneficial in cancer therapy. This review study aimed to evaluate OVs and the mechanisms of their effects on cancer cells.

SUBMITTER: Kooti W 

PROVIDER: S-EPMC8728693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Oncolytic Viruses and Cancer, Do You Know the Main Mechanism?

Kooti Wesam W   Esmaeili Gouvarchin Ghaleh Hadi H   Farzanehpour Mahdieh M   Dorostkar Ruhollah R   Jalali Kondori Bahman B   Bolandian Masoumeh M  

Frontiers in oncology 20211222

The global rate of cancer has increased in recent years, and cancer is still a threat to human health. Recent developments in cancer treatment have yielded the understanding that viruses have a high potential in cancer treatment. Using oncolytic viruses (OVs) is a promising approach in the treatment of malignant tumors. OVs can achieve their targeted treatment effects through selective cell death and induction of specific antitumor immunity. Targeting tumors and the mechanism for killing cancer  ...[more]