A Reactivity-Based ¹⁸F-Labeled Probe for PET Imaging of Oxidative Stress in Chemotherapy-Induced Cardiotoxicity.

ABSTRACT: Oxidative stress underlies the pathology of many human diseases, including the doxorubicin-induced off-target cardiotoxicity in cancer chemotherapies. Since current diagnostic procedures are only capable of monitoring cardiac function, a noninvasive means of detecting biochemical changes in redox status prior to irreversible functional changes is highly desirable for both early diagnosis and prognosis. We designed a novel ¹⁸F-labeled molecular probe, ¹⁸F-FPBT, for the direct detection of superoxide in vivo using positron emission tomography (PET). ¹⁸F-FPBT was radiosynthesized in one step by nucleophilic radiofluorination. In vitro, ¹⁸F-FPBT showed rapid and selective oxidation by superoxide (around 60% in 5 min) compared to other p

SUBMITTER: Mota F 

PROVIDER: S-EPMC8728736 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature