Circulating inflammatory monocytes contribute to impaired influenza vaccine responses in HIV-infected participants.

ABSTRACT:

Objective

Antibody responses are often impaired in old age and in HIV-positive (HIV+) infection despite virologic control with antiretroviral therapy but innate immunologic determinants are not well understood.

Design

Monocytes and natural killer cells were examined for relationships to age, HIV infection and influenza vaccine responses.

Methods

Virologically suppressed HIV+ (n = 139) and HIV-negative (HIV-) (n = 137) participants classified by age as young (18-39 years), middle-aged (40-59 years) and old (≥60 years) were evaluated preinfluenza and postinfluenza vaccination.

Results

Prevaccination frequencies of inflammatory monocytes were highest in old HIV+ and HIV-, with old HIV+ exhibiting higher frequency of integrin CD11b on inflammatory monocytes that wa

SUBMITTER: George VK 

PROVIDER: S-EPMC8728748 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature