Impact of achondroplasia on Latin American patients: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Achondroplasia (ACH), the most common form of disproportionate short stature, is caused by a pathogenic variant in the fibroblast growth factor receptor 3 gene. Recent advances in drug therapy for ACH have highlighted the importance of elucidating the natural history and socioeconomic burden of this condition. Recognition that there are many potential issues for the patient with ACH is the first step in planning cost-effective interventions in Latin America (LATAM), a vast geographic territory comprising countries with multicultural characteristics and wide socioeconomic differences. We conducted a systematic literature review to characterize the impact of ACH on affected individuals and on healthcare resources in LATAM countries.

Methods

Searches of the global me

SUBMITTER: Fano V 

PROVIDER: S-EPMC8728937 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature