Muscle weakness as an additional criterion for grading sarcopenia-related prognosis in patients with cancer.

ABSTRACT:

Background

Low muscle strength has been pointed out as a key characteristic of sarcopenia, but the prognostic significance of muscle function next to reduced skeletal muscle mass (SMM) in patients with cancer has been scantily investigated.

Methods

Data on muscle strength by handgrip (HG) dynamometry and total-body SMM estimated by bioelectrical impedance analysis (BIA) of Italian and German patients with cancer observed prospectively until death or censoring were analysed (N = 1076). Patients were stratified in four risk categories based on low HG (<10th percentiles of age and gender-specific normative values) and low total-body SMM according to SMM index cutoffs (<10.75 and <6.75 kg/m² in men and women, respectively).

Results

During a median follow-up of

SUBMITTER: Cereda E 

PROVIDER: S-EPMC8729063 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature