Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming.

ABSTRACT:

Background

Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been recognized as a crucial driver of cancer progression. Adiponectin demonstrates a wide range of metabolic activities for the modulation of lipid metabolism under physiological conditions. However, the biological actions of adiponectin in cancer-specific lipid metabolism and its role in the regulation of cancer cell growth remain elusive.

Methods

The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, a

SUBMITTER: Pham DV 

PROVIDER: S-EPMC8729140 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature