Machine learning-based predictions of dietary restriction associations across ageing-related genes.

ABSTRACT:

Background

Dietary restriction (DR) is the most studied pro-longevity intervention; however, a complete understanding of its underlying mechanisms remains elusive, and new research directions may emerge from the identification of novel DR-related genes and DR-related genetic features.

Results

This work used a Machine Learning (ML) approach to classify ageing-related genes as DR-related or NotDR-related using 9 different types of predictive features: PathDIP pathways, two types of features based on KEGG pathways, two types of Protein-Protein Interactions (PPI) features, Gene Ontology (GO) terms, Genotype Tissue Expression (GTEx) expression features, GeneFriends co-expression features and protein sequence descriptors. Our findings suggested that features biased towards curated

SUBMITTER: Vega Magdaleno GD 

PROVIDER: S-EPMC8729156 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature