Dataset Information

Cancer-related changes and low-to-moderate exposure to welding fumes: A longitudinal study.

ABSTRACT:

Objective

This study tested for an association between early cancer-related biomarkers and low-to-moderate exposure to fumes from welding mild steel.

Methods

Male, non-smoking participants from southern Sweden were recruited and examined (N=338, 171 welders and 167 controls); of these, 78 welders and 96 controls were examined on two occasions six years apart. Exposure to welding fumes was evaluated by measuring respirable dust, welding years, and cumulative exposure. DNA methylation of CpG sites within the cancer-related genes AHRR, F2RL3, and B3GNTL1 was measured by pyrosequencing and relative mitochondrial DNA copy number and telomere length were measured by qPCR in whole-blood samples. Multivariate models were used for longitudinal analysis.