Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA.

ABSTRACT: Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-κB activation.

SUBMITTER: Kour S 

PROVIDER: S-EPMC8729175 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature