The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg cell plasticity.

ABSTRACT:

Background

Type 2 immunity can be modulated by regulatory T (Treg) cell activity. It has been suggested that the deubiquitinase cylindromatosis (CYLD) plays a role in the development or function of Treg cells, implying that it could be important for normal protective immunity, where type 2 responses are prevalent.

Objective

We sought to investigate the role of CYLD in Treg cell function and T_H2 cell immune responses under steady-state conditions and during helminth infection.

Methods

Foxp3-restricted CYLD conditional knockout (KO) mice were examined in mouse models of allergen-induced airway inflammation and Nippostrongylus brasiliensis infection. We performed multiplex magnetic bead assays, flow cytometry, and quantitative PCR to understand how a lack of C

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8729234 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature