Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease.

ABSTRACT:

Background and objectives

Moderate coffee consumption has been associated with lower risk of CKD; however, the exact biologic mechanisms underlying this association are unknown. Metabolomic profiling may identify metabolic pathways that explain the association between coffee and CKD. The goal of this study was to identify serum metabolites associated with coffee consumption and examine the association between these coffee-associated metabolites and incident CKD.

Design, setting, participants, & measurements

Using multivariable linear regression, we identified coffee-associated metabolites among 372 serum metabolites available in two subsamples of the Atherosclerosis Risk in Communities study (ARIC; n=3811). Fixed effects meta-analysis was used to pool the results from

SUBMITTER: He WJ 

PROVIDER: S-EPMC8729408 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature