Poly-IgA Complexes and Disease Severity in IgA Nephropathy.

ABSTRACT:

Background and objectives

Poly-IgA immune complex formation and glomerular deposition play a key role in IgA nephropathy. Our study sought to develop a new methodology for one-step serologic detection of poly-IgA levels.

Design, setting, participants, & measurements

A novel ELISA method using recombinant CD89 as a "capturing" probe was established for detecting poly-IgA immune complex in plasma. We applied semiquantitative measurements of these poly-IgA indices in patients recruited at Peking University First Hospital who had IgA nephropathy or other kidney disease types, as compared with healthy controls. The longitudinal trend of the poly-IgA index and the association with pathologic parameters and treatment responses were evaluated. Finally, we analyzed the molecular comp

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8729420 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature