Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation.

ABSTRACT:

Background and objectives

Age and comorbidity-related sarcopenia represent a main cause of muscle dysfunction in patients on long-term hemodialysis. However, recent findings suggest muscle abnormalities that are not associated with sarcopenia. The aim of this study was to isolate functional and cellular muscle abnormalities independently of other major confounding factors, including malnutrition, age, comorbidity, or sedentary lifestyle, which are common in patients on maintenance hemodialysis. To overcome these confounding factors, alterations in skeletal muscle were analyzed in highly selected patients on long-term hemodialysis undergoing kidney transplantation.

Design, setting, participants, & measurements

In total, 22 patients on long-term hemodialysis scheduled for kidn

SUBMITTER: Souweine JS 

PROVIDER: S-EPMC8729424 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature