Collectin11 and Complement Activation in IgA Nephropathy.

ABSTRACT:

Background and objectives

IgA nephropathy is the most common primary GN worldwide. Previous research demonstrated that collectin11, an initiator of the complement lectin pathway, was involved in both AKI and chronic tubulointerstitial fibrosis. Here, we investigated the potential role of collectin11 in the pathogenesis of IgA nephropathy.

Design, setting, participants, & measurements

The deposition of collectin11 and other complement proteins was detected in glomeruli of 60 participants with IgA nephropathy by immunofluorescence. In vitro, human mesangial cells were treated with IgA1-containing immune complexes derived from participants with IgA nephropathy. Then, the expression of collectin11 in mesangial cells was examined by quantitative RT-PCR and immunofluorescen

SUBMITTER: Wei M 

PROVIDER: S-EPMC8729485 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature