Classification of Uremic Toxins and Their Role in Kidney Failure.

ABSTRACT: Advances in our understanding of uremic retention solutes, and improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and classification of uremic toxins. A consensus conference was held to develop recommendations for an updated definition and classification scheme on the basis of a holistic approach that incorporates physicochemical characteristics and dialytic removal patterns of uremic retention solutes and their linkage to clinical symptoms and outcomes. The major focus is on the removal of uremic retention solutes by hemodialysis. The identification of representative biomarkers for different classes of uremic retention solutes and their correlation to clinical symptoms and outcomes may fa

SUBMITTER: Rosner MH 

PROVIDER: S-EPMC8729494 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature