APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19.

ABSTRACT:

Background and objectives

Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the APOL1 are responsible for a portion of this higher risk. We sought to assess the odds of AKI conferred by APOL1 risk alleles in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design, setting, participants, & measurements

Black Americans who tested positive for coronavirus disease 2019 (COVID-19) were genotyped to determine APOL1 risk allele status. We assessed the incidence of AKI, persistent AKI, and AKI requiring KRT within 21 days of the PCR-based diagnosis. Outcomes were adjusted for age, sex, body mass index, hypertension, eGFR, and use

SUBMITTER: Larsen CP 

PROVIDER: S-EPMC8729502 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature