Ertugliflozin and Slope of Chronic eGFR: Prespecified Analyses from the Randomized VERTIS CV Trial.

ABSTRACT:

Background and objectives

A reduction in the rate of eGFR decline, with preservation of ≥0.75 ml/min per 1.73 m² per year, has been proposed as a surrogate for kidney disease progression. We report results from prespecified analyses assessing effects of ertugliflozin versus placebo on eGFR slope from the eValuation of ERTugliflozin effIcacy and Safety CardioVascular outcomes (VERTIS CV) trial (NCT01986881).

Design, setting, participants, & measurements

Patients with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease were randomized to placebo, ertugliflozin 5 mg, and ertugliflozin 15 mg (1:1:1). The analyses compared the effect of ertugliflozin (pooled doses, n=5499) versus placebo (n=2747) on eGFR slope per week and per

SUBMITTER: Cherney DZI 

PROVIDER: S-EPMC8729577 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature