Net Endogenous Acid Excretion and Kidney Allograft Outcomes.

ABSTRACT:

Background and objectives

High dietary acid load may accelerate a decline in kidney function. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients, and whether venous bicarbonate mediates this association.

Design, setting, participants, & measurements

We used data from 642 kidney transplant recipients with a functioning graft ≥1 year after transplantation. Net endogenous acid production was estimated using food frequency questionnaires and, alternatively, 24-hour urinary urea and potassium excretion to estimate net endogenous acid production. We defined the composite kidney end point as a doubling of plasma creatinine or graft failure. Multivariable Cox regression analyses, adjusted for potential confounder

SUBMITTER: Yeung SMH 

PROVIDER: S-EPMC8729579 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature