De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples.
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ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC8729799 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
<i>De novo</i> generation of a bright blue fluorophore from 2-oxoglutarate in biological samples.
Kim Yumin Y Kang Sangyoon S Lee Byung Hun BH Song Youngjun Y Kang Sunah S Park Hye Yoon HY Lee Yan Y
Chemical science 20211207 2
We discovered the generation of a new bright blue fluorophore from a particular type of amine and 2-oxoglutarate (2-OG) under mild conditions without any chemical additives. Two β-aminoethylamine molecules and three 2-OG molecules form an unprecedented 2-pyridone structure with a fused γ-lactam ring (DTPP) <i>via</i> complex reactions including double decarboxylation and quintuple dehydration. The DTPP fluorophore shows a high quantum yield (80%) and photostability. The great potential of the pr ...[more]
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