High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients.

ABSTRACT:

Background

The clinical significance of accumulating toxic terminal metabolites such as oxalate in patients with kidney failure is not well understood.

Methods

To evaluate serum oxalate concentrations and risk of all-cause mortality and cardiovascular events in a cohort of patients with kidney failure requiring chronic dialysis, we performed a post-hoc analysis of the randomized German Diabetes Dialysis (4D) Study; this study included 1255 European patients on hemodialysis with diabetes followed-up for a median of 4 years. The results obtained via Cox proportional hazards models were confirmed by competing risk regression and restricted cubic spline modeling in the 4D Study cohort and validated in a separate cohort of 104 US patients on dialysis after a median

SUBMITTER: Pfau A 

PROVIDER: S-EPMC8729829 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature