Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease.

ABSTRACT:

Background

In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized, placebo-controlled trial, the sodium-glucose cotransporter 2 inhibitor dapagliflozin significantly reduced risk of kidney failure and prolonged survival in patients with CKD with or without type 2 diabetes.

Methods

Adults with eGFR of 25-75 ml/min per 1.73 m² and urinary albumin-to-creatinine ratio of 200-5000 mg/g had been randomized to receive dapagliflozin 10 mg/d or placebo. Here, we conducted a prespecified analysis of dapagliflozin's effects in patients with stage 4 CKD (eGFR,30 ml/min per 1.73 m²) at baseline. The primary end point was a composite of time to ≥50% sustained decline in eGFR, ESKD, or kidney or cardiovascular death. Se

SUBMITTER: Chertow GM 

PROVIDER: S-EPMC8729835 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature